Catherine Lefebvre began her double bass studies at the Conservatoire de musique de Montréal, where she received her First Prize unanimously. After her studies at the Conservatoire National Supérieur de Musique in Paris, she was heard in various Quebec symphonic, baroque, string and chamber music ensembles.

She has been teaching young people in several High Schools of the Montreal area. She is currently an affiliate professor at the Préconservatoire de musique de Montréal. For more than 25 years she has been playing with Orchestre Métropolitain and she is a member of the Orchestre symphonique de Longueuil. She has been a member of the Orchestre symphonique de Laval since 1990.